黄酮类抗氧化剂的构-效关系

天然黄酮是广泛存在于自然界的酚类抗氧化剂之一,其抗氧化活性与清除自由基的能力密切相关.综述了几种研究抗氧化剂活性中常用的自由基检测方法与评价指标,并详细分析了结构因素影响黄酮类化合物抗氧化活性的机制与规律.认为黄酮类化合物的抗氧化活性主要取决于羟基的相对位置而非数目,具有色原酮结构的黄酮2-3位上不饱和双键也会在一定程度上增强其抗氧化活性,C环吸电子性质或羟基成甙则会使天然黄酮抗氧化能力降低,与金属离子的络合也是黄酮阻止自由基氧化的途径之一.对黄酮类抗氧化剂构-效关系的研究为筛选高效抗氧化剂和天然黄酮的结构修饰提供了理论依据.     

数据挖掘在数字图书馆个性化服务中的应用

提供个性化信息服务是数字图书馆发展的必由之路.用户建模是实现个性化服务的关键,利用数据挖掘技术进行用户建模是个可行的高效的手段.     

我院大学语文课程教学的调查分析与对策

大学语文作为高校人文素质通识课程在培养学生人文素质方面有着不可替代的重要地位。本文通过对我校大学语文课程的教学调查,一方面总结教学经验,一方面为适应时代发展,根据课程特点,从教学内容、教学手段、作业考试等方面提出改革措施,使该课程更好为学校的人才培养目标服务。     

陡脉冲不可逆性电击穿恶性肿瘤细胞的机理

电场的基本特性是对处于场中的物质有力的作用.在陡脉冲电场作用下,细胞膜内外表面有很强的电场分布,同时由于细胞膜的介电常数与细胞外液、细胞质的不同,从电磁场理论出发,必然有作用于细胞膜表面的电场应力.仿真计算结果表明,外加电场的作用使得细胞膜受到来自细胞外液与细胞质两个方向的压力,作用在恶性肿瘤细胞膜上的电场应力的数量级比正常细胞大1个数量级.因此,在陡脉冲电场的作用下,恶性肿瘤细胞比正常细胞具有更大的敏感性,这种电场应力的作用势必对恶性肿瘤细胞膜造成巨大的损伤,使得细胞的生存环境和遗传物质受到严重破坏,并导致细胞发生不可逆性电击穿而死亡.     

应用自然伽马曲线反演陇东地区延安组沉积旋回

自然伽马曲线包含丰富的地质信息,能够很好地反映由气候变化引起的地层旋回.采用频谱分析对鄂尔多斯盆地陇东地区延安组湖沼相自然伽马测井曲线进行反演,可以得出地层中很好地保存了高频的米兰科维奇旋回,认为研究区延安组地层中的沉积旋回主要受古气候变化的控制,其中偏心率周期引起的地层旋回厚度变化范围为7.86～16.75 m;地轴倾角周期引起的地层旋回厚度变化范围为2.34～6.36 m;岁差周期引起的地层旋回厚度变化范围为1.14～2.96 m.频谱分析法可用于测井曲线进行高频沉积旋回分析.     

右江盆地晚古生代白云岩与层序地层的关系及其储集性

以广西右江盆地晚古生代白云岩为研究对象,详细研究了白云岩在剖面上的分布与产出的形态, 归纳起来包括5种类型:(1)与硅质岩互层;(2)与灰质泥岩互层;(3)与灰黑色中层含光壳节石的微晶灰岩互层;(4)与灰白色厚层块状生物屑灰岩互层;(5)与厚层块状灰质白云岩、白云质灰岩互层.在此基础上讨论了白云岩的分布与层序地层学的关系,即与LST有关的白云岩主要为一套角砾状白云岩;与TST有关的白云岩主要为薄层状的硅质粉-细晶白云岩或细晶白云岩;与HST有关的白云岩主要为厚层块状中-粗晶白云岩或含残余生物屑结构白云岩.进而研究了白云岩的储集性,讨论了不同类型的白云岩和不同体系域内的白云岩的储集性.这为全面研究白云岩储层提供了基础资料.     

Evidence of widespread selection on standing variation in Europe at height-associated SNPs

Strong signatures of positive selection at newly arising genetic variants are well documented in humans, but this form of selection may not be widespread in recent human evolution. Because many human traits are highly polygenic and partly determined by common, ancient genetic variation, an alternative model for rapid genetic adaptation has been proposed: weak selection acting on many pre-existing (standing) genetic variants, or polygenic adaptation. By studying height, a classic polygenic trait, we demonstrate the first human signature of widespread selection on standing variation. We show that frequencies of alleles associated with increased height, both at known loci and genome wide, are systematically elevated in Northern Europeans compared with Southern Europeans (P < 4.3 × 10(-4)). This pattern mirrors intra-European height differences and is not confounded by ancestry or other ascertainment biases. The systematic frequency differences are consistent with the presence of widespread weak selection (selection coefficients ～10(-3)-10(-5) per allele) rather than genetic drift alone (P < 10(-15)).     

Effects of electromagnetic field and lubricate condition on the surface quality of magnesium alloy billet during LFEC processing

The microstructures of the magnesium billets could be improved markedly by low-frequency electromagnetic casting(LFEC)processing.In fact,the low-frequency electromagnetic field(LFEF)also has favorite effect on the surface quality of billet.However,few public reports on the surface quality of LFEC magnesium billets could be found.Therefore,a new crystallizer with a metal internal sleeve together with a kind of lubricant was designed aiming at lowing surface turning quantity,and the effects of casting velocit...     

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 × 10(-8)), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 × 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases.     

“人文精神”教育下的体育教师角色探析

新世纪的教育以其鲜明的教育理想和浓郁的时代创新气息,呼唤着体育教师角色的转换。体育教师角色的转换正是体育教育在回归"人性"的基础上,在人文关怀的关爱下,以增强体质、增进健康为本质,激发学生的生命热情,发掘学生的精神资源,带着激情,踏着理性的教育。